The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives hypnotics including barbiturates , narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore such agents should either be eliminated or given in reduced dosage in the presence of promethazine hcl see precautions – information for patients and drug interactions .
Information about Promethazine.
Promethazine hydrochloride tablets may lead to potentially fatal respiratory depression.
Read the Patient Information Leaflet if available from your pharmacist before you start taking promethazine and each time you get a refillIf you have any questionsask your doctor or pharmacist.
ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTSAND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGYTHE EXTRAPYRAMIDAL SYMPTOMS WHICH CAN OCCUR.
Promethazine can be administered by mouth in tablet or syrupliquidformby injectionintravenouslyor into the rectum in the form of a suppositoryWhen taking liquid promethazinepatients should use a measuring spoon or cup made specifically for measuring medicationsand not a household spoonThe suppository can only be inserted through the rectumlower part of the large intestine through the anusand should not be swallowed.
EpinephrineBecause of the potential for promethazine to reverse epinephrine’s vasopressor effectepinephrine should NOT be used to treat hypotension associated with promethazine hydrochloride tablets overdose.
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