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Risk of potentially fatal pseudomembranous colitisfungal or bacterial superinfection on prolonged usediscontinue therapy if significant abdominal crampsdiarrheaor passage of blood and mucus occurs.
Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less wellWhen clindamycin is indicated in these patientsthey should be carefully monitored for change in bowel frequency.
Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum.
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