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EverolimusAlthough not studied in vivo or in vitrofluconazole may increase serum concentrations of everolimus through inhibition of CYP3A4.
PimozideAlthough not studied in vitro or in vivoconcomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolismIncreased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsades de pointesCoadministration of fluconazole and pimozide is contraindicatedsee section 4.3
Hepatotoxicity reported with useuse with caution in patients with hepatic impairment.
CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.
Powder for oral suspension contains sucrose and should not be used in patients with hereditary fructoseglucose/galactose malabsorption or sucrase-isomaltase deficiency.
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