This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection.
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Avoid exposure to sunlight or artificial UV rayssunlamps or tanning bedsespecially if you are being treated for psoriasisMethotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen.
Increased side effects from other drugsTaking methotrexate with certain medications raises your risk of side effects from those drugsExamples of these drugs include:
Signs of tumor cell breakdownconfusiontirednessnumbness or tinglingmuscle crampsmuscle weaknessvomitingdiarrheafast or slow heart rateseizure.
Methotrexate has rarely caused serioussometimes fatalside effectsThereforethis medication should be used only to treat cancer or severe diseases caused by an overactive immune systemsuch as psoriasisrheumatoid arthritis
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