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The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19such as omeprazole or esomeprazoleAvoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavixsee DRUG INTERACTIONS
Figure 1Exposure to Clopidogrel Active Metabolite Following Multiple Doses of Plavix 75 mg Alone or with Proton Pump InhibitorsPPIs)
Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.
Tell all of your doctors and your dentist that you are taking PlavixThey should talk to the doctor who prescribed Plavix for you before you have any surgery or invasive procedure.
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