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DiabetesMirtazapine may cause a loss of control of diabetes by increasing blood glucosesugarIf you have diabetes or are at risk for developing diabetesdiscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is needed.
The use of monoamine oxidase inhibitorsMAOIsintended to treat psychiatric disorders with REMERON Tablets or within 14 days of stopping treatment with REMERON is contraindicated because of an increased risk of serotonin syndromeThe use of REMERON within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicatedsee WARNINGS and DOSAGE AND ADMINISTRATION
Mirtazapine is a moderate antagonist at muscarinic receptorsa property that may explain the relatively low incidence of anticholinergic side effects associated with its use.
Adverse events reported since market introductionwhich were temporallybut not necessarily causallyrelated to mirtazapine therapyinclude cases of the ventricular arrhythmia Torsades de PointesIn the majority of these caseshoweverconcomitant drugs were implicatedCases of severe skin reactionsincluding Stevens-Johnson syndromebullous dermatitiserythema multiforme and toxic epidermal necrolysis have also been reportedIncreased creatine kinase blood levels and rhabdomyolysis have also been reported.
Medications other than those listed above may interact with this medicationTell your doctor or prescriber about all prescriptionover-the-counternon-prescriptionand herbal medications that you are takingAlso tell them about any supplements you takeSince caffeinealcoholthe nicotine from cigarettesor street drugs can affect the action of many medicationsyou should let your prescriber know if you use them.
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